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The excess glucose in the urine filtrate acts as an osmotic diuretic. First, a simple definition of osmosis that will never get you into trouble, well seldom, never is an impossible situation. Osmosis is the movement of water through a selective permeable membrane (think cell membrane if you have a tiny mind like me!)from an area of low solute concentration (anything dissolved in water (the solvent) into a area of high solute concentration. In this illustration, due to the large amount of excess glucose in the filtrate, (what the kidney filters from the blood under pressure) the glucose is the . Net result, instead of water being returned to the blood it is flushed out of the body in the urine! Thats called diuresis. A diuretic, in this case, is something that inhibits water reabsorption by the blood from the kidney tubules that results in a hugh urine output that is called Polyuria. The polyuria results in decreased blood volume and dehydration. Thats why a diabetic person experiences excessive thirst. Lets look at how that . Keep in mind a balance is maintained between positive and negative ions in the body. But, in mass movements involving negative charged ketone bodies, they attract and carry positve charged ions like sodium (Na+) and potassium (K+)out of the body fluids as well. This creates an electrolyte imbalance in you, if you are a diabetic out of control. Because of this imbalance you get abdominal pains and may vomit, and the stress reaction (. This rapid water loss, or dehydration, stimulates the hypothalmic thirst centers causing polydipsia or excerssive thirst. If the general body cells cannot take up glucose for metabolism to take place you develop excessive hunger pangs and increase your food consumption accordingly. This is called polyphagia. You sense, correctly, that you are starving to death. Although you have plenty of glucose available, it cannot be used, and the body begins to use the fat and protein stores for metabolism. Hope this helps with your understanding of the course that diabetes follows in a Type I diabetic.
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